University of Charleston

University of Charleston

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Rebecca S. Linger, Ph.D.

Rebecca Linger
Contact Info

rebeccalinger@ucwv.edu

304-357-4998

Professor of Medicinal Chemistry Pharmaceutical and Administrative Sciences

  • Ph.D., Medicinal Chemistry, Purdue University, West Lafayette, IN
  • B.S. Biochemistry, San Francisco State University, San Francisco, CA
  • B.A. Music, San Francisco State University, San Francisco, CA

Publications

  1. Oliver, J.C., Gudihal, R., Burgner, J.W., Pedley, A.M., Zwierko, A.T., Davisson, V.J.,Linger, R.S.Conformational Changes Involving Ammonia Tunnel Formation and Allosteric Control in GMP Synthetase.Archives of Biochemistry and Biophysics 2014, 545, 22-32.
  2. D’Ordine, R.L., Linger, R.S., Thai, C.J., Davisson, V.J. Catalytic zinc site and mechanism of the metalloenzyme PR-AMP Cyclohydrolase. Biochemistry 2012, 51, 5791-5803.
  3. Amaro, R.E., Myers, R.S., Davisson, V.J., Luthey-Schulten, Z.A. A network of conserved interactions regulates the allosteric signal in a glutamine amidotransferase. Biochemistry 2007, 46, 2156-2173.
  4. Myers, R.S., Amaro, R.E., Luthey-Schulten, Z.A., Davisson, V.J. Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase. Biochemistry 2005, 44, 11974-11985.
  5. Schrag, J., Myers, R.S., Davisson, V.J. Crystal structure of Methanococcus thermoautotrophicum HisI: a histidine biosynthetic pathway enzyme. Biochemistry 2005, 44, 10071-10080.
  6. Amaro, R.E., Myers, R.S., Davisson, V.J., Luthey-Schulten, Z.A. Structural elements of imidazole glycerol phosphate synthase exclude water to optimize ammonia transfer. Biophysical Journal 2005, 89, 1-13, Cover.
  7. Myers, R.S., Jensen, J.R., Deras, I.L., Smith, J.L., Davisson, V.J. Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase. Biochemistry 2003, 42, 7013-7022.
  8. Chaudhuri, B.N., Lange, S.C., Myers, R.S., Davisson, V.J., Smith, J.L. Towards understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerol phosphate synthase: crystal structures of a ternary complex and the free enzyme. Biochemistry 2003, 42, 7003-7012.
  9. Chaudhuri, B.N., Lange, S.C., Myers, R.S., Chittur, S.V., Davisson, V.J., Smith, J.L. Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (b/a)8 barrel joins two active sites. Structure 2001, 9, 987-997.
  10. Myers, R.S., Paton, P.T., Dastgah, A., Martell, J.R., Berkman, C.E. A general high-performance liquid chromatography-based assay for the hydrolysis of N-acyl glutamates. Analytical Biochemistry 1999, 275, 187-191.

Invited Speaking Engagements

  1. “Ethnobotanical Uses of Appalachian Plants” Clay Center Lunchtime Talks, Charleston, WV, September 11, 2013.
  2. “Folk Remedies and Reliable Edible Plants of Appalachia” 2013 Wild Edibles Festival, Calvin W. Price Appalachian Enrichment Series, Hillsboro, Pocahontas Co., WV, April 20, 2013.
  3. “Medicinal Plants of Kanawha State Forest” Clay Center Lunchtime Talks, Charleston, WV, August 8, 2012.
  4. “Edible Plants of Southern Appalachia” Clay Center Lunchtime Talks, Charleston, WV, July 13, 2011.
  5. “Medicinal and Edible Plants of Southern Appalachia” West Virginia Department of Natural Resources, Kanawha Valley Master Naturalist Program, Charleston, WV June 24, 2011
  6. “Medicinal Plants of Southern Appalachia” 28th Annual Sue Browning Wildflower Hike at Chief Logan State Park (Museum in the Park),Logan, WV, April 16, 2011
  7. “Medicinal Plants of Southern Appalachia” American Chemical Society Kanawha Valley Section, Charleston, WV, March 24, 2011
  8. “Medicinal Plants of Southern Appalachia” Southern West Virginia Community and Technical College, Williamson, WV. March 2, 2011
  9. “Appalachian Herbals for Health: How they work and how they can hurt (Potential Herb-Drug Interactions)” Clay Center Lunchtime Talks, Charleston, WV August 11, 2010.
  10. “Edible and Medicinal Plants of Southern Appalachia” West Virginia Rural Health Conference 2009, Daniels, WV, October 23, 2009.
  11. “Edible and Medicinal Plants of Southern Appalachia” UCSOP Convocations, University of Charleston, Charleston, WV September, 2009.
  12. “Edible and Medicinal Plants of Southern Appalachia” Xi Tau, University of Charleston, Charleston, WV September, 2009.
  13. “Medicinal Plants of Southern Appalachia” Clay Center Lunchtime Talks, Charleston, WV August, 2009.

Grants

  1. 2012      West Virginia IDeA Network for Biomedical Research Excellence Grant, $12,500
  2. 2011      University of Charleston School of Pharmacy, Teacher of the Year 2010-2011
  3. 2011      West Virginia IDeA Network for Biomedical Research Excellence Grant, $10,000
  4. 2010      West Virginia IDeA Network for Biomedical Research Excellence Grant, $20,000
  5. 2010      American Recovery and Reinvestment Act, Undergraduate Research Award, $5,800
  6. 2009      West Virginia IDeA Network for Biomedical Research Excellence Grant, $10,000
  7. 2008      West Virginia IDeA Network for Biomedical Research Excellence Grant, $10,000
  8. 2007      West Virginia IDeA Network for Biomedical Research Excellence Grant, $10,000

  • Program Coordinator, West Virginia Master Naturalist Program, Kanawha Valley Chapter
  • Experienced Chicken Rancher
  • Land-locked Sailor

Rebecca Linger (nee Myers) was born in Southern Ohio and learned to sail on the small lakes of Ohio. At eleven years old, she and her family moved to San Francisco where she sailed on San Francisco Bay with the Sea Scouts for over ten years.

While she first chose to pursue music education in college, she had high affinity for science and once graduated, she chose to return to complete a second degree in Biochemistry. Her choice of Purdue University for graduate school allowed her to return to the Midwest to be closer to her extended family.

At Purdue she found her passion with mechanistic enzymology and has successfully garnered over $100,000 in funding for her research laboratory to investigate several projects related to this subject. She helped publish the first complete crystal structure of imidazole glycerol phosphate synthase and PR-AMP cyclohydrolase. She has published proposed mechanisms of allosteric activity of both IGP synthase and GMP synthetase.

She was awarded the Elmer M and Joy B. Plein Fellowship for Excellence in Pharmacy Education at the University of Washington in Seattle and it was during this tenure that she expanded her knowledge of the natural environment, volunteering as a Docent Naturalist at Discovery Park in Seattle. She continues her love of the outdoors with the West Virginia Master Naturalist Program as the program coordinator for the Kanawha Valley Chapter.